FMS ONCOGENE PRODUCT GP140
\ˌɛfˌɛmˈɛs ˈɒnkə͡ʊd͡ʒˌiːn pɹˈɒdʌkt d͡ʒˌiːpˈiː wˈɒnhˈʌndɹədən fˈɔːti], \ˌɛfˌɛmˈɛs ˈɒnkəʊdʒˌiːn pɹˈɒdʌkt dʒˌiːpˈiː wˈɒnhˈʌndɹədən fˈɔːti], \ˌɛ_f_ˌɛ_m_ˈɛ_s ˈɒ_n_k_əʊ_dʒ_ˌiː_n p_ɹ_ˈɒ_d_ʌ_k_t dʒ_ˌiː_p_ˈiː w_ˈɒ_n_h_ˈʌ_n_d_ɹ_ə_d_ə_n f_ˈɔː_t_i]\
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Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120 (v-fms) is post-translationally modified to generate gp140 (v-fms).
By DataStellar Co., Ltd
