FILIPIN IV
\fˈɪlɪpˌɪn ɹˌə͡ʊmən fˈɔː], \fˈɪlɪpˌɪn ɹˌəʊmən fˈɔː], \f_ˈɪ_l_ɪ_p_ˌɪ_n ɹ_ˌəʊ_m_ə_n_ f_ˈɔː]\
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A complex of polyene antibiotics obtained from Streptomyces filipinensis. Filipin III alters membrane function by interfering with membrane sterols, inhibits mitochondrial respiration, and is proposed as an antifungal agent. Filipins I, II, and IV are less important.
By DataStellar Co., Ltd
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.