EXCESSIVE SOMNOLENCE DISORDER
\ɛksˈɛsɪv sˈɒmnələns dɪsˈɔːdə], \ɛksˈɛsɪv sˈɒmnələns dɪsˈɔːdə], \ɛ_k_s_ˈɛ_s_ɪ_v s_ˈɒ_m_n_ə_l_ə_n_s d_ɪ_s_ˈɔː_d_ə]\
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Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., IDIOPATHIC HYPERSOMNOLENCE; NARCOLEPSY; and KLEINE-LEVIN SYNDROME) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, MENTAL DISORDERS, and SLEEP APNEA SYNDROME). (From J Neurol Sci 1998 Jan 8;153 (2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.