ERYTHROCYTE ANION EXCHANGER
\ɜːɹˈɪθɹəsˌa͡ɪt ˈana͡ɪən ɛkst͡ʃˈe͡ɪnd͡ʒə], \ɜːɹˈɪθɹəsˌaɪt ˈanaɪən ɛkstʃˈeɪndʒə], \ɜː_ɹ_ˈɪ_θ_ɹ_ə_s_ˌaɪ_t ˈa_n_aɪ_ə_n ɛ_k_s_tʃ_ˈeɪ_n_dʒ_ə]\
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A ubiquitous membrane transport protein found in the plasma membrane of diverse cell types and tissues, and in nuclear, mitochondrial, and Golgi membranes. It is the major integral transmembrane protein of the erythrocyte plasma membrane, comprising 25% of the total membrane protein. It exists as a dimer and performs the important function of allowing the efficient transport of bicarbonate across erythrocyte cell membranes in exchange for chloride ion.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.