ENKEPHALINASE 24.11
\ɛnkˈɛfɐlˌɪne͡ɪs twˈɛntifˈɔː pɔ͡ɪnt wˈɒn wˈɒn], \ɛnkˈɛfɐlˌɪneɪs twˈɛntifˈɔː pɔɪnt wˈɒn wˈɒn], \ɛ_n_k_ˈɛ_f_ɐ_l_ˌɪ_n_eɪ_s t_w_ˈɛ_n_t_i_f_ˈɔː p_ɔɪ_n_t w_ˈɒ_n w_ˈɒ_n]\
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Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA), an important marker in the diagnosis of human acute lymphocytic leukemia. EC 3.4.24.11.
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