ENKEPHALINASE
\ɛnkˈɛfɐlˌɪne͡ɪs], \ɛnkˈɛfɐlˌɪneɪs], \ɛ_n_k_ˈɛ_f_ɐ_l_ˌɪ_n_eɪ_s]\
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Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA), an important marker in the diagnosis of human acute lymphocytic leukemia. EC 3.4.24.11.
By DataStellar Co., Ltd
Word of the day
hydromorphic
- [Greek] Structurally adapted to an aquatic environment, as organs of water plants.