ENDOTHELIUM DERIVED RELAXANT FACTOR
\ˌɛndə͡ʊθˈiːli͡əm dɪɹˈa͡ɪvd ɹɪlˈaksənt fˈaktə], \ˌɛndəʊθˈiːliəm dɪɹˈaɪvd ɹɪlˈaksənt fˈaktə], \ˌɛ_n_d_əʊ_θ_ˈiː_l_iə_m d_ɪ_ɹ_ˈaɪ_v_d ɹ_ɪ_l_ˈa_k_s_ə_n_t f_ˈa_k_t_ə]\
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A free radical gas produced endogenously by a variety of mammalian cells. It is synthesized from arginine by a complex reaction, catalyzed by NITRIC OXIDE SYNTHASE. Nitric oxide is endothelium-derived relaxing factor. It is released by the vascular endothelium and mediates the relaxation induced by some vasodilators such as acetylcholine and bradykinin. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic guanylate cyclase and thus elevates intracellular levels of cyclic GMP.
By DataStellar Co., Ltd
Nearby Words
- endotheliotoxin
- endothelium
- endothelium dependent relaxing factor
- endothelium derived growth factor synthase
- endothelium derived nitric oxide
- Endothelium Derived Relaxant Factor
- endothelium derived relaxing factor
- endothelium derived vasoconstrictor factor receptors
- endothelium derived vasoconstrictor factors
- endotheliums
- endotheloid