ENDODERMAL SINUS TUMOR
\ˌɛndə͡ʊdˈɜːmə͡l sˈa͡ɪnəs tjˈuːmə], \ˌɛndəʊdˈɜːməl sˈaɪnəs tjˈuːmə], \ˌɛ_n_d_əʊ_d_ˈɜː_m_əl s_ˈaɪ_n_ə_s t_j_ˈuː_m_ə]\
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An unusual and aggressive tumor of germ-cell origin that reproduces the extraembryonic structures of the early embryo. It is the most common malignant germ cell tumor found in children. It is characterized by a labyrinthine glandular pattern of flat epithelial cells and rounded papillary processes with a central capillary (Schiller-Duval body). The tumor is rarely bilateral. Before the use of combination chemotherapy, the tumor was almost invariably fatal. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1189)
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