ENDOCRINE CELLS OF GUT
\ˈɛndə͡ʊkɹˌa͡ɪn sˈɛlz ɒv ɡˈʌt], \ˈɛndəʊkɹˌaɪn sˈɛlz ɒv ɡˈʌt], \ˈɛ_n_d_əʊ_k_ɹ_ˌaɪ_n s_ˈɛ_l_z ɒ_v ɡ_ˈʌ_t]\
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Cells found throughout the lining of the gastrointestinal tract that contain regulatory peptide hormones and/or biogenic amines. The substances are located in secretory granules and act in an endocrine or paracrine manner. Some of these substances are also found in neurons in the gut. There are at least 15 different types of endocrine cells of the gut. Some take up amine precursors and have been called APUD CELLS. However, most endocrine cells of the gut apparently have endodermal rather than neuroectodermal origin, so the relationship with APUD cells is not clear.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.