EMPTY SELLA SYNDROMES
\ˈɛmpti sˈɛlə sˈɪndɹə͡ʊmz], \ˈɛmpti sˈɛlə sˈɪndɹəʊmz], \ˈɛ_m_p_t_i s_ˈɛ_l_ə s_ˈɪ_n_d_ɹ_əʊ_m_z]\
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A condition associated with underdevelopment or absence of the diaphragma sellae which allows herniation of the meninges into the SELLA TURCICA. The pituitary gland becomes compressed against the walls of the sella and the sella may enlarge. Female gender; OBESITY; PSEUDOTUMOR CEREBRI; and pituitary ADENOMA are associated with this condition, which may present with HEADACHE. (From Joynt, Clinical Neurology, 1992, Ch36, p85)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.