DISGERMINOMA
\dɪsd͡ʒˌɜːmɪnˈə͡ʊmə], \dɪsdʒˌɜːmɪnˈəʊmə], \d_ɪ_s_dʒ_ˌɜː_m_ɪ_n_ˈəʊ_m_ə]\
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A malignant ovarian neoplasm, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. It is the counterpart of the classical seminoma of the testis, to which it is both grossly and histologically identical. Dysgerminomas comprise 16% of all germ cell tumors but are rare before the age of 10, although nearly 50% occur before the age of 20. They are generally considered of low-grade malignancy but may spread if the tumor extends through its capsule and involves lymph nodes or blood vessels. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1646
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Immunologic Desensitization
- Immunosuppression by the administration increasing doses antigen. Though exact mechanism is not clear, therapy results increase in serum levels of allergen-IMMUNOGLOBULIN G, suppression specific IgE, and an suppressor T-cell activity.