DIFFUSE CUTANEOUS MASTOCYTOSIS
\dɪfjˈuːz kjuːtˈe͡ɪni͡əs mˌastəsɪtˈə͡ʊsɪs], \dɪfjˈuːz kjuːtˈeɪniəs mˌastəsɪtˈəʊsɪs], \d_ɪ_f_j_ˈuː_z k_j_uː_t_ˈeɪ_n_iə_s m_ˌa_s_t_ə_s_ɪ_t_ˈəʊ_s_ɪ_s]\
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The most common form of mastocytosis. It occurs primarily in children and is typically characterized by multiple persistent small, reddish-brown, hyperpigmented, pruritic macules and papules. They are located most commonly on the trunk, but seen also on the extremities, head, and neck. (Dorland, 27th ed)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.