DIABETIC ACIDOSES
\dˌa͡ɪəbˈɛtɪk ɐsˈɪdə͡ʊzɪz], \dˌaɪəbˈɛtɪk ɐsˈɪdəʊzɪz], \d_ˌaɪ_ə_b_ˈɛ_t_ɪ_k ɐ_s_ˈɪ_d_əʊ_z_ɪ_z]\
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Complication of diabetes resulting from severe insulin deficiency coupled with an absolute or relative increase in glucagon concentration. The metabolic acidosis is caused by the breakdown of adipose stores and resulting increased levels of free fatty acids. Glucagon accelerates the oxidation of the free fatty acids producing excess ketone bodies (ketosis).
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.