DESMOPLASTIC MEDULLOBLASTOMA
\dɪsməplˈastɪk mˌɛdəlˌɒblastˈə͡ʊmə], \dɪsməplˈastɪk mˌɛdəlˌɒblastˈəʊmə], \d_ɪ_s_m_ə_p_l_ˈa_s_t_ɪ_k m_ˌɛ_d_ə_l_ˌɒ_b_l_a_s_t_ˈəʊ_m_ə]\
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A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
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Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.