DEFECTIVE INTERFERING VIRUSES
\dɪfˈɛktɪv ˌɪntəfˈi͡əɹɪŋ vˈa͡ɪɹəsɪz], \dɪfˈɛktɪv ˌɪntəfˈiəɹɪŋ vˈaɪɹəsɪz], \d_ɪ_f_ˈɛ_k_t_ɪ_v ˌɪ_n_t_ə_f_ˈiə_ɹ_ɪ_ŋ v_ˈaɪ_ɹ_ə_s_ɪ_z]\
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Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.