DEFECTIVE HYBRIDS
\dɪfˈɛktɪv hˈa͡ɪbɹɪdz], \dɪfˈɛktɪv hˈaɪbɹɪdz], \d_ɪ_f_ˈɛ_k_t_ɪ_v h_ˈaɪ_b_ɹ_ɪ_d_z]\
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Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.
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Word of the day
Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.