DACTINOMYCIN
\dˈaktɪnˌɒmɪsˌɪn], \dˈaktɪnˌɒmɪsˌɪn], \d_ˈa_k_t_ɪ_n_ˌɒ_m_ɪ_s_ˌɪ_n]\
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An antitumor antibiotic derived from Streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
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