\kə͡ʊkˈe͡ɪn], \kəʊkˈeɪn], \k_əʊ_k_ˈeɪ_n]\
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An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
By DataStellar Co., Ltd
By Stedman, Thomas Lathrop
By William R. Warner
By James Champlin Fernald
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- Any point circumscribed area, irritation of which will give rise to functional action or disturbance elsewhere.