CLOSTRIDIUM HISTOLYTICUM COLLAGENASE
\kləstɹˈɪdi͡əm hˈɪstəlˌɪtɪkəm kˈɒle͡ɪd͡ʒnˌe͡ɪs], \kləstɹˈɪdiəm hˈɪstəlˌɪtɪkəm kˈɒleɪdʒnˌeɪs], \k_l_ə_s_t_ɹ_ˈɪ_d_iə_m h_ˈɪ_s_t_ə_l_ˌɪ_t_ɪ_k_ə_m k_ˈɒ_l_eɪ_dʒ_n_ˌeɪ_s]\
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A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.
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