CLOSTRIDIAL NEUROTOXIN
\kləstɹˈɪdɪəl njˈuːɹə͡ʊtˌɒksɪn], \kləstɹˈɪdɪəl njˈuːɹəʊtˌɒksɪn], \k_l_ə_s_t_ɹ_ˈɪ_d_ɪ__ə_l n_j_ˈuː_ɹ_əʊ_t_ˌɒ_k_s_ɪ_n]\
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The toxin elaborated by Clostridium tetani. It is a protein with a molecular weight of about 150,000, probably consisting of two fragments, tetanolysin being the hemolytic and tetanospasmin the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal convulsions.
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