CLOSEUP

\klˈə͡ʊsʌp], \klˈə‍ʊsʌp], \k_l_ˈəʊ_s_ʌ_p]\

Definitions of CLOSEUP

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MEN IIa

  • type multiple endocrine neoplasia characterized by virtually 100% incidence medullary thyroid carcinoma, a 50% pheochromocytoma, and lesser adenomas associated hyperparathyroidism. condition always transmitted through autosomal dominant inheritance. Genetic testing can identify individuals with the trait in early infancy. Treatment is usually excision of enlarged parathyroid glands. (From Holland et al., Cancer Medicine, 3d ed, pp1172-75)
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