CLASSIC GALACTOSEMIA
\klˈasɪk ɡˌalɐktə͡ʊsˈiːmi͡ə], \klˈasɪk ɡˌalɐktəʊsˈiːmiə], \k_l_ˈa_s_ɪ_k ɡ_ˌa_l_ɐ_k_t_əʊ_s_ˈiː_m_iə]\
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A group of inherited enzyme deficiencies which feature elevations of GALACTOSE in the blood. This condition may be associated with deficiencies of GALACTOKINASE; UDPGLUCOSE-HEXOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; or UDPGLUCOSE 4-EPIMERASE. The classic form is caused by UDPglucose-Hexose-1-Phosphate Uridylyltransferase deficiency, and presents in infancy with FAILURE TO THRIVE; VOMITING; and INTRACRANIAL HYPERTENSION. Affected individuals also may develop MENTAL RETARDATION; JAUNDICE; hepatosplenomegaly; ovarian failure (OVARIAN FAILURE, PREMATURE); and cataracts. (From Menkes, Textbook of Child Neurology, 5th ed, pp61-3)
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Vertebral Artery Dissection
- Dissection wall artery, leading to formation an aneurysm that occlude vessel. Thrombus give rise emboli. Cervical fractures or related NECK INJURIES and CRANIOCEREBRAL TRAUMA are commonly associated conditions, although this process may occur spontaneously. Ischemia, infarction, hemorrhage in the vascular distribution of affected vertebral artery complicate condition.