CHRONIC SUBDURAL HEMATOMAS
\kɹˈɒnɪk sˈʌbdjʊ͡əɹə͡l hˌɛmɐtˈə͡ʊməz], \kɹˈɒnɪk sˈʌbdjʊəɹəl hˌɛmɐtˈəʊməz], \k_ɹ_ˈɒ_n_ɪ_k s_ˈʌ_b_d_j_ʊə_ɹ_əl h_ˌɛ_m_ɐ_t_ˈəʊ_m_ə_z]\
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Chronic accumulation of blood in the subdural space, most frequently occurring over the lateral and superior aspects of a cerebral hemisphere. Clinical manifestations may be delayed for days to weeks, when affected individuals may present with confusion, drowsiness, hemiparesis, ATAXIA, APHASIA, and other signs of neurologic dysfunction. The condition tends to occur after the age of 50 years. It may be spontaneous, follow CRANIOCEREBRAL TRAUMA, or occur in association with bleeding disorders, the use of anticoagulant medication, locally invasive tumors, and other disorders. (From Adams et al., Principles of Neurology, 6th ed, p887)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.