CHOLINESTERASE INHIBITORS
\kˈɒla͡ɪnstəɹˌe͡ɪz ɪnhˈɪbɪtəz], \kˈɒlaɪnstəɹˌeɪz ɪnhˈɪbɪtəz], \k_ˈɒ_l_aɪ_n_s_t_ə_ɹ_ˌeɪ_z ɪ_n_h_ˈɪ_b_ɪ_t_ə_z]\
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Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
By DataStellar Co., Ltd
Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.