CHOLERA TOXIN PROTOMER A
\kˈɒləɹə tˈɒksɪn pɹˈə͡ʊtə͡ʊməɹ ˈe͡ɪ], \kˈɒləɹə tˈɒksɪn pɹˈəʊtəʊməɹ ˈeɪ], \k_ˈɒ_l_ə_ɹ_ə t_ˈɒ_k_s_ɪ_n p_ɹ_ˈəʊ_t_əʊ_m_ə_ɹ ˈeɪ]\
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The enterotoxin from Vibrio cholerae. It is a protein that consists of two major components, the heavy (H) or A peptide and the light (L) or B peptide or choleragenoid. The B peptide anchors the protein to intestinal epithelial cells, while the A peptide, enters the cytoplasm, and activates adenylate cyclase, and production of cAMP. Increased levels of cAMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
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Word of the day
tinctura quininae ammoniata
- A preparation made by dissolving quinin sulphate in alcohol [Br. Ph.].