CHILDHOOD CEREBRAL ASTROCYTOMA
\t͡ʃˈa͡ɪldhʊd səɹˈiːbɹə͡l ˌastɹəsɪtˈə͡ʊmə], \tʃˈaɪldhʊd səɹˈiːbɹəl ˌastɹəsɪtˈəʊmə], \tʃ_ˈaɪ_l_d_h_ʊ_d s_ə_ɹ_ˈiː_b_ɹ_əl ˌa_s_t_ɹ_ə_s_ɪ_t_ˈəʊ_m_ə]\
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Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.
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