CHEMOKINE RECEPTORS
\kˌiːmə͡ʊkˈa͡ɪn ɹɪsˈɛptəz], \kˌiːməʊkˈaɪn ɹɪsˈɛptəz], \k_ˌiː_m_əʊ_k_ˈaɪ_n ɹ_ɪ_s_ˈɛ_p_t_ə_z]\
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Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. The receptors are members of the seven-transmembrane G protein-coupled receptor family. Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.