CEREBROSIDE SULFATASE
\səɹˈiːbɹəsˌa͡ɪd sˈʌlfɐtˌe͡ɪs], \səɹˈiːbɹəsˌaɪd sˈʌlfɐtˌeɪs], \s_ə_ɹ_ˈiː_b_ɹ_ə_s_ˌaɪ_d s_ˈʌ_l_f_ɐ_t_ˌeɪ_s]\
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An enzyme that catalyzes the hydrolysis of cerebroside 3-sulfate (sulfatide) to yield a cerebroside and inorganic sulfate. A marked deficiency of arylsulfatase A, which is considered the heat-labile component of cerebroside sulfatase, has been demonstrated in all forms of metachromatic leukodystrophy (LEUKODYSTROPHY, METACHROMATIC). EC 3.1.6.8.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.