CD98 ANTIGENS
\sˌiːdˈiː nˈa͡ɪntiˈe͡ɪt ˈantɪd͡ʒˌɛnz], \sˌiːdˈiː nˈaɪntiˈeɪt ˈantɪdʒˌɛnz], \s_ˌiː_d_ˈiː n_ˈaɪ_n_t_i__ˈeɪ_t ˈa_n_t_ɪ_dʒ_ˌɛ_n_z]\
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A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (CD98 HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (CD98 LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.