CATHEPSIN B1
\kˈaθɪpsˌɪn bˈiː wˈɒn], \kˈaθɪpsˌɪn bˈiː wˈɒn], \k_ˈa_θ_ɪ_p_s_ˌɪ_n b_ˈiː w_ˈɒ_n]\
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A lysosomal cysteine proteinase which hydrolyzes proteins, with a specificity resembling that of papain. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in demyelination, emphysema, rheumatoid arthritis, and neoplastic infiltration. EC 3.4.22.1.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.