CAROTID STENOSIS
\kəɹˈɒtɪd stɛnˈə͡ʊsɪs], \kəɹˈɒtɪd stɛnˈəʊsɪs], \k_ə_ɹ_ˈɒ_t_ɪ_d s_t_ɛ_n_ˈəʊ_s_ɪ_s]\
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Narrowing or stricture of the internal, common, or external carotid artery, most often as a result of atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce thrombus formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a transient ischemic attack (ISCHEMIC ATTACK, TRANSIENT) or CEREBROVASCULAR ACCIDENT. Emboli which travel to the eye may manifest as AMAUROSIS FUGAX (temporary blindness). (From Adams et al., Principles of Neurology, 6th ed, pp822-3)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.