\kˌɑːdɪə͡ʊtˈɒnɪk stˈɛɹɔ͡ɪdz], \kˌɑːdɪəʊtˈɒnɪk stˈɛɹɔɪdz], \k_ˌɑː_d_ɪ__əʊ_t_ˈɒ_n_ɪ_k s_t_ˈɛ_ɹ_ɔɪ_d_z]\
Definitions of CARDIOTONIC STEROIDS
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Substances obtained from species of Digitalis, Strophanthus, and other plants that contain specific steroid glycosides or their semisynthetic derivatives and used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the Na (+)-K (+)-exchanging ATPase and they are often used in cell biological studies for that purpose.
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