CARCINOGENIC ACTIVITY TEST
\kˌɑːsɪnə͡ʊd͡ʒˈɛnɪk aktˈɪvɪti tˈɛst], \kˌɑːsɪnəʊdʒˈɛnɪk aktˈɪvɪti tˈɛst], \k_ˌɑː_s_ɪ_n_əʊ_dʒ_ˈɛ_n_ɪ_k a_k_t_ˈɪ_v_ɪ_t_i t_ˈɛ_s_t]\
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Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.
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Collagen Induced Arthritis
- ARTHRITIS that is induced in experimental animals. Immunological and infectious agents can be used to develop models. These methods include injections of stimulators the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.