\bˈʌθɪˌɒna͡ɪn sʌlfˈɒksɪmˌiːn], \bˈʌθɪˌɒnaɪn sʌlfˈɒksɪmˌiːn], \b_ˈʌ_θ_ɪ__ˌɒ_n_aɪ_n s_ʌ_l_f_ˈɒ_k_s_ɪ_m_ˌiː_n]\
Definitions of BUTHIONINE SULFOXIMINE
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A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270 (33):1945-7)
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- in a very painful manner; "the progress was agonizingly slow" In an excruciating manner.