BRCA1 PROTEIN
\bˌiːˌɑːsˌiːˈe͡ɪ wˈɒn pɹˈə͡ʊtiːn], \bˌiːˌɑːsˌiːˈeɪ wˈɒn pɹˈəʊtiːn], \b_ˌiː__ˌɑː_s_ˌiː__ˈeɪ w_ˈɒ_n p_ɹ_ˈəʊ_t_iː_n]\
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The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270 (5237):713,789-91)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.