BENIGN CEREBELLAR NEOPLASMS
\bɪnˈa͡ɪn sˈɛɹɪbˌɛlə nˈiːə͡ʊplˌazəmz], \bɪnˈaɪn sˈɛɹɪbˌɛlə nˈiːəʊplˌazəmz], \b_ɪ_n_ˈaɪ_n s_ˈɛ_ɹ_ɪ_b_ˌɛ_l_ə n_ˈiː__əʊ_p_l_ˌa_z_ə_m_z]\
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Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.