AUTISM DEMENTIA ATAXIA LOSS OF PURPOSEFUL HAND USE SYNDROME
\ˈɔːtɪzəm dɪmˈɛnʃəɹ atˈe͡ɪksi͡ə lˈɒs ɒv pˈɜːpəsfə͡l hˈand jˈuːs sˈɪndɹə͡ʊm], \ˈɔːtɪzəm dɪmˈɛnʃəɹ atˈeɪksiə lˈɒs ɒv pˈɜːpəsfəl hˈand jˈuːs sˈɪndɹəʊm], \ˈɔː_t_ɪ_z_ə_m d_ɪ_m_ˈɛ_n_ʃ_ə_ɹ a_t_ˈeɪ_k_s_iə l_ˈɒ_s ɒ_v p_ˈɜː_p_ə_s_f_əl h_ˈa_n_d j_ˈuː_s s_ˈɪ_n_d_ɹ_əʊ_m]\
Definitions of AUTISM DEMENTIA ATAXIA LOSS OF PURPOSEFUL HAND USE SYNDROME
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An inherited disorder that is associated with X-linked transmission and may be lethal in utero to hemizygous males. Clinically, birth and development in affected females is normal until the age of 6-25 months, when progressive loss of voluntary control of hand movements and communication skills, ataxia, stereotypic hand movements, seizures, autistic behavior, intermittent hyperventilation, and hyperammonemia appear. (From Menkes, Textbook of Child Neurology, 5th ed, p199)
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