ATYPICAL CLUSTER HEADACHE
\e͡ɪtˈɪpɪkə͡l klˈʌstə hˈɛde͡ɪk], \eɪtˈɪpɪkəl klˈʌstə hˈɛdeɪk], \eɪ_t_ˈɪ_p_ɪ_k_əl k_l_ˈʌ_s_t_ə h_ˈɛ_d_eɪ_k]\
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A syndrome characterized by daily episodes of intense periorbital pain that recur over a period of 6-12 weeks that may be followed by a period of remission of months to years. The pain is non-throbbing, has a duration of 30-60 minutes and tends to occur at night or at regular intervals during the day. Unilateral rhinorrhea, conjunctival injection, lacrimation, facial flushing, and miosis frequently accompany the headaches, which primarily affect young adult males. (Adams et al., Principles of Neurology, 6th ed, p181)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.