ASIALOGLYCOPROTEINS
\ˈe͡ɪʃəlˌɒɡlɪkˌɒpɹə͡ʊtˌiːnz], \ˈeɪʃəlˌɒɡlɪkˌɒpɹəʊtˌiːnz], \ˈeɪ_ʃ_ə_l_ˌɒ_ɡ_l_ɪ_k_ˌɒ_p_ɹ_əʊ_t_ˌiː_n_z]\
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Endogenous glycoproteins from which sialic acid has been removed by the action of sialidases. They bind tightly to their cell surface receptor which is located on hepatocyte plasma membranes. After internalization by adsorptive endocytosis they are delivered to lysosomes for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with hepatic cirrhosis or hepatitis.
By DataStellar Co., Ltd
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