ARACHIDONATE 12 LIPOXYGENASE
\ɐɹˈakɪdə͡ʊnˌe͡ɪt twˈɛlv lˈɪpəksˌɪd͡ʒənˌe͡ɪs], \ɐɹˈakɪdəʊnˌeɪt twˈɛlv lˈɪpəksˌɪdʒənˌeɪs], \ɐ_ɹ_ˈa_k_ɪ_d_əʊ_n_ˌeɪ_t t_w_ˈɛ_l_v l_ˈɪ_p_ə_k_s_ˌɪ_dʒ_ə_n_ˌeɪ_s]\
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An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in platelets. EC 1.13.11.31.
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Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.