\ɐpˈə͡ʊz ˈiːkwə͡lz ˈa͡ɪ tˈiː], \ɐpˈə‍ʊz ˈiːkwə‍lz ˈa‍ɪ tˈiː], \ɐ_p_ˈəʊ_z _ˈiː_k_w_əl_z___ ˈaɪ__ t_ˈiː]\
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  • ap'poz-[=i]t, adj. adapted: suitable.--adv. AP'POSITELY.--n. AP'POSITENESS. [L. appositus, pa.p. of appon[)e]re, to put to--ad, to, pon[)e]re, to put.]
1908 - Chambers's Twentieth Century Dictionary of the English Language
By Thomas Davidson

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Proto Oncogene Proteins c erbB 2

  • cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.
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