ANTIFIBRILLATORY AGENTS
\ˌantɪfˈɪbɹɪlətəɹˌi ˈe͡ɪd͡ʒənts], \ˌantɪfˈɪbɹɪlətəɹˌi ˈeɪdʒənts], \ˌa_n_t_ɪ_f_ˈɪ_b_ɹ_ɪ_l_ə_t_ə_ɹ_ˌi_ ˈeɪ_dʒ_ə_n_t_s]\
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Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.