ALCOHOLIC AXONAL NEUROPATHIES
\ˌalkəhˈɒlɪk ˈaksɒnə͡l njuːɹˈɒpəθɪz], \ˌalkəhˈɒlɪk ˈaksɒnəl njuːɹˈɒpəθɪz], \ˌa_l_k_ə_h_ˈɒ_l_ɪ_k ˈa_k_s_ɒ_n_əl n_j_uː_ɹ_ˈɒ_p_ə_θ_ɪ_z]\
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A condition where damage to the peripheral nervous system (including the peripheral elements of the autonomic nervous system) is associated with chronic ingestion of alcoholic beverages. The disorder may be caused by a direct effect of alcohol, an associated nutritional deficiency, or a combination of factors. Clinical manifestations include variable degrees of weakness; ATROPHY; PARESTHESIAS; pain; loss of reflexes; sensory loss; diaphoresis; and postural hypotension. (From Arch Neurol 1995;52 (1):45-51; Adams et al., Principles of Neurology, 6th ed, p1146)
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Word of the day
Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.