AIDS RELATED DEMENTIA COMPLEX
\ˈe͡ɪdz ɹɪlˈe͡ɪtɪd dɪmˈɛnʃə kˈɒmplɛks], \ˈeɪdz ɹɪlˈeɪtɪd dɪmˈɛnʃə kˈɒmplɛks], \ˈeɪ_d_z ɹ_ɪ_l_ˈeɪ_t_ɪ_d d_ɪ_m_ˈɛ_n_ʃ_ə k_ˈɒ_m_p_l_ɛ_k_s]\
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A neurologic condition associated with the ACQUIRED IMMUNONDEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefication, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332 (14):934-40)
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SQ10,643
- A serotonin antagonist with limited antihistaminic, anticholinergic, and immunosuppressive activity.