AIDS ENCEPHALOPATHIES
\ˈe͡ɪdz ɛnsˌɛfɐlˈɒpəθɪz], \ˈeɪdz ɛnsˌɛfɐlˈɒpəθɪz], \ˈeɪ_d_z ɛ_n_s_ˌɛ_f_ɐ_l_ˈɒ_p_ə_θ_ɪ_z]\
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A neurologic condition associated with the ACQUIRED IMMUNONDEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefication, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332 (14):934-40)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.