AIDS DEMENTIA COMPLEX
\ˈe͡ɪdz dɪmˈɛnʃə kˈɒmplɛks], \ˈeɪdz dɪmˈɛnʃə kˈɒmplɛks], \ˈeɪ_d_z d_ɪ_m_ˈɛ_n_ʃ_ə k_ˈɒ_m_p_l_ɛ_k_s]\
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A neurologic condition associated with the ACQUIRED IMMUNONDEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefication, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332 (14):934-40)
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Word of the day
Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.