ACETYL 2 METHYLCHOLINE CHLORIDE
\ˈasɪtˌa͡ɪl tˈuː mˈiːθɪlkˌɒliːn klˈɔːɹa͡ɪd], \ˈasɪtˌaɪl tˈuː mˈiːθɪlkˌɒliːn klˈɔːɹaɪd], \ˈa_s_ɪ_t_ˌaɪ_l t_ˈuː m_ˈiː_θ_ɪ_l_k_ˌɒ_l_iː_n k_l_ˈɔː_ɹ_aɪ_d]\
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A quarternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolysed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
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Hypoglossal Neuropathy
- twelfth cranial (hypoglossal) nuclei. fascicles are located in medulla, exits via hypoglossal foramen innervates muscles tongue. Lower brain stem diseases, including ischemia MOTOR NEURON affect nuclei fascicles. nerve may also be injured by diseases of the posterior fossa or skull base. Clinical manifestations include unilateral musculature and lingual dysarthria, with deviation tongue towards side weakness upon attempted protrusion.