\sˈɪks θˈa͡ʊzənd ən twˈɛntinˈa͡ɪn ˈɛm], \sˈɪks θˈaʊzənd ən twˈɛntinˈaɪn ˈɛm], \s_ˈɪ_k_s θ_ˈaʊ_z_ə_n_d ə_n t_w_ˈɛ_n_t_i_n_ˈaɪ_n ˈɛ_m]\
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A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
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