20 EPI 1ALPHA,25 DIHYDROXYCHOLECALIFEROL
\twˈɛnti ˈɛpɪ wˈɒn ˈalfə twˈɛntifˈa͡ɪv da͡ɪhˈa͡ɪdɹəksˌɪkə͡ʊlkəlˌɪfəɹˌɒl], \twˈɛnti ˈɛpɪ wˈɒn ˈalfə twˈɛntifˈaɪv daɪhˈaɪdɹəksˌɪkəʊlkəlˌɪfəɹˌɒl], \t_w_ˈɛ_n_t_i_ ˈɛ_p_ɪ w_ˈɒ_n ˈa_l_f_ə t_w_ˈɛ_n_t_i_f_ˈaɪ_v d_aɪ_h_ˈaɪ_d_ɹ_ə_k_s_ˌɪ_k_əʊ_l_k_ə_l_ˌɪ_f_ə_ɹ_ˌɒ_l]\
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The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.