12 LIPOXYGENASE
\twˈɛlv lˈɪpəksˌɪd͡ʒənˌe͡ɪs], \twˈɛlv lˈɪpəksˌɪdʒənˌeɪs], \t_w_ˈɛ_l_v l_ˈɪ_p_ə_k_s_ˌɪ_dʒ_ə_n_ˌeɪ_s]\
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An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in platelets. EC 1.13.11.31.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.